Potassium Bromide → 4-(Tetrahydro-furan-2-ylmethyl)-piperazine-1-carboxylic acid 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl ester

HRID 1179959노트

반응식

HRID 1179959 반응식
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:22])[NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)=[CH:7][CH:6]=1)=[O:3].[O:23]1[CH2:27][CH2:26][CH2:25][CH:24]1[CH2:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1.[K+].[Br-].C(O)[C@H](O)[C@H]1OC(=O)C(O)=C1O>>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][CH2:13][NH:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:32]3[CH2:31][CH2:30][N:29]([CH2:28][CH:24]4[CH2:25][CH2:26][CH2:27][O:23]4)[CH2:34][CH2:33]3)=[O:3])=[CH:6][CH:7]=2)=[O:22])=[CH:16][CH:17]=1

참가 물질

5

반응물 4

HCID 253877Potassium BromideHCID 27372651-(Tetrahydro-2-furylmethyl)piperazineHCID 54670067L-Ascorbic AcidHCID 865892134-[2-(4-Chloro-phenyl)-ethylcarbamoyl]-phenyl chloroformate

생성물 1

HCID 695192894-(Tetrahydro-furan-2-ylmethyl)-piperazine-1-carboxylic acid 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl ester수율 12%

실험 절차

The title compound was prepared from 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl chloroformate and 1-(tetrahydrofuran-2-ylmethyl)-piperazine, yield 12%. White crystals, m.p. 220-221° C.; IR (KBr): ν 1708 (ester C═O), 1660 (amide C═O) cm−1.

출처 및 근거

ORD 기록
ord-5d9e3b5e583a4506bf5fb4e4b9c38ad7
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279470B2

반응 노트

불러오는 중…