1-[(Pyridin-3-yl)methyl]piperazine → 4-Pyridin-3-ylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

HRID 1180007노트

반응식

HRID 1180007 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:2]=1.Cl[C:15]([O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24](=[O:32])[NH:25][CH2:26][CH2:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:20][CH:19]=1)=[O:16]>ClCCl>[CH3:29][C:28]([CH3:31])([CH3:30])[CH2:27][CH2:26][NH:25][C:24]([C:21]1[CH:20]=[CH:19][C:18]([O:17][C:15]([N:11]2[CH2:12][CH2:13][N:8]([CH2:7][C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[CH2:9][CH2:10]2)=[O:16])=[CH:23][CH:22]=1)=[O:32]

참가 물질

4

반응물 2

HCID 1569751-[(Pyridin-3-yl)methyl]piperazineHCID 220478734-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate

생성물 1

HCID 695191174-Pyridin-3-ylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title product was prepared from 1-pyridin-3-ylmethyl-piperazine was dissolved in dichloromethane (5 ml). 4-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate (0.35 mmol) was added at room temperature. The reaction mixture was stirred for 16 h and evaporated to dryness and subjected to preparative HPLC (method C) (88%, light yellow oil). HPLC-MS m/z=425.4 (M+1), Rt: 2.33 min.

후처리

  1. customevaporated to dryness

출처 및 근거

ORD 기록
ord-578e194b6ae645a58fb684229c864082
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279470B2

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