Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nicotinic Acid → Methyl-phenyl-carbamic Acid 4-{2-[(pyridine-3-carbonyl)-amino]-ethyl}-phenyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nicotinic Acid | HCID 938 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | Methyl-phenyl-carbamic acid 4-(2-amino-ethyl)phenyl Ester | HCID 69520583 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl-phenyl-carbamic Acid 4-{2-[(pyridine-3-carbonyl)-amino]-ethyl}-phenyl Ester | HCID 69517683 | 15% |
반응 단계
A solution of 3-pyridinecarboxylic acid (0.3 mmol), EDAC (0.36 mmol) and triethylamine (0.36 mmol) in CH2Cl2 (10 mL) was added N-hydroxybenzoetriazole and N-methyl-N-phenyl-carbamic acid 4-(2-amino-ethyl)phenyl ester as its TFA salt (0.3 mmol). The mixture was stir-stirred 16 h at rt and purified by preparative HPLC (Gilson) to give the title compound in 15% yield as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07279470B2 |
| 출처 데이터셋 | uspto-grants-2007_10 |
| ORD ID | ord-dfcf06294c9041219636b8986f5ec125 |
| 출처 메모 | uspto-grants-2007_10 |