Tyrosol → Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester

HRID 1180048

반응식

HRID 1180048 반응식
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[CH3:11][N:12]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:13](Cl)=[O:14]>C(Cl)Cl>[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:13](=[O:14])[N:12]([CH3:11])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 10393TyrosolHCID 77969Carbamic chloride, N-methyl-N-phenyl-

생성물 1

HCID 69520342Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester수율 99.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 4-(2-Hydroxyethyl)phenol (10 mmol) and 4-diazabicyclo[2.2.2]octane (DABCO) (10 mmol) in CH2Cl2 (30 mL) was added N-methyl-N-phenylcarbamoyl chloride (10 mmol). The reaction mixture was stirred for 16 hours at rt, added CH2Cl2 (20 mL), and washed with 1M aqueous HCl and brine. The organic phase was dried (MgSO4) and evaporated to give the 2.69 g (99%) of the title compound as crystals.

후처리

  1. washwashed with 1M aqueous HCl and brine
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated

출처 및 근거

ORD 기록
ord-7cb4b87fd2f641f0985c21c6fa665b9f
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279470B2

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