Trifluoroacetic acid → Methyl-phenyl-carbamic Acid 4-{2-[4-(2-dimethylamino-ethyl)-phenoxy]-ethyl}-phenyl Ester

HRID 1180055

반응식

C(O)(C(F)(F)F)=O.[OH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18](=[O:27])[N:19]([CH3:26])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][CH:12]=1.[CH3:28][N:29]([CH3:39])[CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][C:35](O)=[CH:34][CH:33]=1>>[CH3:39][N:29]([CH3:28])[CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:8][CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18](=[O:27])[N:19]([CH3:26])[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:15][CH:16]=2)=[CH:34][CH:33]=1

참가 물질

반응물 3

HCID 6422Trifluoroacetic acid

HCID 68313Hordenine

HCID 69520342Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester

생성물 1

HCID 69519061Methyl-phenyl-carbamic Acid 4-{2-[4-(2-dimethylamino-ethyl)-phenoxy]-ethyl}-phenyl Ester수율 92%

실험 절차

The title compound was prepared as its TFA salt in 92% yield as an oil using methyl-phenyl-carbamic acid 4-(2-hydroxy-ethyl)-phenyl ester and 4-(2-dimethylaminoethyl)-phenol.

출처 및 근거

ORD 기록: ord-bdf161e7ae244e8a865ffb45d4b3abdd
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07279470B2

연결된 노트

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