Trifluoroacetic acid → Methyl-phenyl-carbamic acid 4-[2-(imidazol-1-yloxy)-ethyl]-phenyl ester

반응식

C(O)(C(F)(F)F)=O.[OH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18](=[O:27])[N:19]([CH3:26])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][CH:12]=1.Cl.O[N:30]1[CH:34]=[CH:33][N:32]=[CH:31]1>>[N:30]1([O:8][CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18](=[O:27])[N:19]([CH3:26])[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:15][CH:16]=2)[CH:34]=[CH:33][N:32]=[CH:31]1

참가 물질

반응물 3

HCID 6422Trifluoroacetic acid

HCID 103131281-hydroxyimidazole Hydrochloride

HCID 69520342Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester

생성물 1

HCID 69517669Methyl-phenyl-carbamic acid 4-[2-(imidazol-1-yloxy)-ethyl]-phenyl ester수율 79%

실험 절차

The title compound was prepared as its TFA salt in 79% yield as an oil using methyl-phenyl-carbamic acid 4-(2-hydroxy-ethyl)-phenyl ester and 1-hydroxyimidazole hydrochloride.

출처 및 근거

ORD 기록: ord-8cc4b67bf52c47b690ff3fed7eadd142
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07279470B2

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