Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoic Acid → Rizatriptan Benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoic Acid | HCID 243 | — |
| 반응물 | Rizatriptan | HCID 5078 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | Isopropyl Acetate | HCID 7915 | — |
| 생성물 | Rizatriptan Benzoate | HCID 77997 | 80.1% |
반응 단계
A solution of 147 mg (1.2 mmoles) of benzoic acid in 1 ml of isopropyl acetate was added slowly to a solution of 300 mg (1.1 mmoles) of the rizatriptan base in 2.6 ml of isopropyl alcohol. The mixture was stirred at room temperature for 30 minutes and evaporated to dryness, and the residue recrystallised from ethanol to give 345 mg (80%) of rizatriptan benzoate as a white crystalline solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07279581B2 |
| 출처 데이터셋 | uspto-grants-2007_10 |
| ORD ID | ord-abd210887dcd46259279e7ded4ab972d |
| 출처 메모 | uspto-grants-2007_10 |