Methanol → 2-[(4-{[4-(Tert-butoxycarbonyl)piperazin-1-yl]carbonyl}phenyl)(phenyl)methoxy]-4-methylpentanoic acid potassium salt

HRID 1180379노트

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HRID 1180379 반응식
C[O:2][C:3]([CH:5]([O:10][CH:11]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:12]1[CH:32]=[CH:31][C:15]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)=[O:17])=[CH:14][CH:13]=1)[CH2:6][CH:7]([CH3:9])[CH3:8])=[O:4].CO.[OH-].[K+:42]>C1COCC1>[K+:42].[C:27]([O:26][C:24]([N:21]1[CH2:22][CH2:23][N:18]([C:16]([C:15]2[CH:31]=[CH:32][C:12]([CH:11]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[O:10][CH:5]([CH2:6][CH:7]([CH3:8])[CH3:9])[C:3]([O-:4])=[O:2])=[CH:13][CH:14]=2)=[O:17])[CH2:19][CH2:20]1)=[O:25])([CH3:29])([CH3:30])[CH3:28]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 69473035Tert-butyl 4-{4-[[1-(methoxycarbonyl)-3-methylbutoxy](phenyl)methyl]benzoyl}piperazine-1-carboxylate

생성물 1

HCID 694738852-[(4-{[4-(Tert-butoxycarbonyl)piperazin-1-yl]carbonyl}phenyl)(phenyl)methoxy]-4-methylpentanoic acid potassium salt

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
70 °C

실험 절차

To a solution of tert-butyl 4-{4-[[1-(methoxycarbonyl)-3-methylbutoxy](phenyl)methyl]benzoyl}piperazine-1-carboxylate from step 3 (0.6 g, 1.1 mmol) in THF (6.5 mL) was added methanol (2.2 mL) and 1.0N aqueous potassium hydroxide solution (2.2 mL, 2.2 mmol). The mixture was heated at 70° C. for 20 minutes and then cooled down to room temperature. The crude mixture was evaporated under reduced pressure and co-evaporated twice with toluene. The solid residue obtained was used as such in the next step.

후처리

  1. temperaturecooled down to room temperature
  2. customThe crude mixture was evaporated under reduced pressure
  3. customThe solid residue obtained

출처 및 근거

ORD 기록
ord-f2ef7583725840fe84541965e437bcfe
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279478B2

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