Potassium Hydroxide → 2-[(4-Bromophenyl)(1,3-thiazol-2-yl)methoxy]-4-methylpentanoic acid potassium salt

반응식

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[S:20][CH:21]=[CH:22][N:23]=2)[O:9][CH:10]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1.[OH-].[K+:25]>>[K+:25].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[S:20][CH:21]=[CH:22][N:23]=2)[O:9][CH:10]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:11]([O-:13])=[O:12])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 14797Potassium Hydroxide

HCID 69472556HCID 69472556, 화합물

생성물 1

HCID 694713692-[(4-Bromophenyl)(1,3-thiazol-2-yl)methoxy]-4-methylpentanoic acid potassium salt

실험 절차

Using the same protocol as described in example 17, step 5, methyl 2-[(4-bromophenyl)(1,3-thiazol-2-yl)methoxy]-4-methylpentanoate from step 2 (441 mg, 1.11 mmol) was hydrolysed with potassium hydroxide. The solid residue obtained was used as such in the next step.

후처리

customThe solid residue obtained

출처 및 근거

ORD 기록: ord-45dd58730ee647dc8c83dbe0ea6f7582
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07279478B2

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