Methanol → Candesartan Cilexetil

HRID 11805

반응식

HRID 11805 반응식
[CH3:1][CH2:2][O:3][C:4]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[C:25]([C:26]4[N:30](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[N:29]=[N:28][N:27]=4)=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[C:50]([O:52][CH:53]([O:55][C:56]([O:58][CH:59]2[CH2:64][CH2:63][CH2:62][CH2:61][CH2:60]2)=[O:57])[CH3:54])=[O:51])[N:5]=1.C1(C)C=CC=CC=1.CO>O>[CH3:1][CH2:2][O:3][C:4]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:25]=3[C:26]3[N:27]=[N:28][NH:29][N:30]=3)=[CH:16][CH:15]=2)[C:11]2[C:10]([C:50]([O:52][CH:53]([O:55][C:56]([O:58][CH:59]3[CH2:60][CH2:61][CH2:62][CH2:63][CH2:64]3)=[O:57])[CH3:54])=[O:51])=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 1140TolueneHCID 11029254Trityl candesartan cilexetil

생성물 1

HCID 2540Candesartan Cilexetil

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), toluene (60 ml), methanol (60 ml), and water (1 ml) was gently refluxed for about 12 h. The reaction was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. 60° C. to obtain viscous oil of candesartan cilexetil as a residue (36.5 g).

후처리

  1. temperaturewas gently refluxed for about 12 h
  2. customThe solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C

출처 및 근거

ORD 기록
ord-cf2755c8bda948af8d1a138c3269dbe4
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098342B2

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