Sodium Bicarbonate → 1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylic Acid Methyl Ester

HRID 1180559노트

반응식

HRID 1180559 반응식
[CH3:1][O:2][C:3](=[O:34])[C:4]([N:6]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:26](=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[S:7]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)(=[O:9])=[O:8])=[CH2:5].C(=O)(O)[O-].[Na+]>CO>[CH3:1][O:2][C:3]([CH:4]1[N:6]([S:7]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[N:25]([C:26](=[O:33])[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:5]1)=[O:34]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 186130262-[(2-Benzoylamino-benzyl)-(4-methoxy-benzenesulfonyl)-amino]-acrylic acid methyl ester

생성물 1

HCID 186127381-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylic Acid Methyl Ester수율 92%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The procedure of Example 35 was followed using the product from Example 34 (500 mg, 1.04 mmol) and sodium bicarbonate (114 mg, 1.35 mmoml) in methanol (5 ml) to give 460 mg (92%) of the product.

출처 및 근거

ORD 기록
ord-ae071371034a49b2bfefde67b00b7921
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07282496B2

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