Acetone → 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxy-2(5H)-furanone

HRID 1180662노트

반응식

HRID 1180662 반응식
[CH3:1][C:2]([CH3:4])=[O:3].S(=O)(=O)(O)O.[O:10]=[C:11]1[O:17][C@H:16]([C@H:18]([CH2:20]O)[OH:19])[C:14]([OH:15])=[C:12]1[OH:13]>>[CH3:1][C:2]1([CH3:4])[O:19][CH:18]([CH:16]2[O:17][C:11](=[O:10])[C:12]([OH:13])=[C:14]2[OH:15])[CH2:20][O:3]1

참가 물질

4

반응물 3

HCID 180AcetoneHCID 1118Sulfuric AcidHCID 54670067L-Ascorbic Acid

생성물 1

HCID 546765085-(2,2-dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxy-2(5H)-furanone수율 115.4%

실험 절차

With nitrogen substitution, 557.8 grams (9.6 moles) of acetone was cooled to −5 degrees C., 54.3 grams (0.2 moles) of 28% fuming sulfuric acid was dripped, and 176.1 grams (1.0 mole) of L-ascorbic acid was added. The mixture was then reacted at the temperature of the previous step for 17 hours, filtered and washed with cold acetone to obtain 249.5 grams of 5,6-O-isopropylidene-L-ascorbic acid (86.7% in purity) in the form of a wet cake.

후처리

  1. customThe mixture was then reacted at the temperature of the previous step for 17 hours
  2. filtrationfiltered
  3. washwashed with cold acetone

출처 및 근거

ORD 기록
ord-791e98c0e714494494edee84fc7b4241
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07282597B2

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