Tetrahydrofuran → Methyl 2-allyloctanoate

HRID 1180696노트

반응식

HRID 1180696 반응식
COC(N([C@@H](C1C=CC=CC=1)C)C(=O)[CH:7]([CH2:14][CH:15]=[CH2:16])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=O.[CH3:26][O-:27].[Na+].C1C[O:32][CH2:31]C1>>[CH2:11]([CH:10]([CH2:9][CH2:8][CH2:7][CH2:14][CH2:15][CH3:16])[C:26]([O:32][CH3:31])=[O:27])[CH:12]=[CH2:13]

참가 물질

4

반응물 3

HCID 8028TetrahydrofuranHCID 10942334Sodium MethoxideHCID 69502051N-methyloxycarbonyl-N-(2-allyloctanoyl)-1-(R)-phenylethylamine

생성물 1

HCID 23117480Methyl 2-allyloctanoate수율 55%

실험 절차

A solution of 0.345 g (1.0 mmol) of N-methyloxycarbonyl-N-(2-allyloctanoyl)-1-(R)-phenylethylamine in 5 ml of THF was cooled to 0° C., 0.386 g (2.0 mmol) of NaOMe (28% solution in methanol) was added, and the mixture was stirred for 22 hours. The reaction was terminated by addition of 2 ml of 1 N hydrochloric acid, and the product was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, the solvent was distilled off, and the residue was quantitated by GC. Thus was obtained 0.109 g (55%) of the title compound.

후처리

  1. customThe reaction was terminated by addition of 2 ml of 1 N hydrochloric acid
  2. extractionthe product was extracted with ethyl acetate
  3. dry with materialThe extract was dried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-33279d8c9f2c4023a10c45151be4af4a
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07282605B2

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