Cyclobutane-1,1-diyldimethanol → [1-({[5-(4-chlorophenyl)-1-methyl-1H-imidazol-2-yl]sulfanyl}methyl)cyclobutyl]methanol

반응식

O[CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]1.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]([CH3:21])[C:19]([SH:22])=[N:18][CH:17]=2)=[CH:12][CH:11]=1>>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[N:20]([CH3:21])[C:19]([S:22][CH2:2][C:3]3([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]3)=[N:18][CH:17]=2)=[CH:14][CH:15]=1

참가 물질

반응물 2

HCID 4498243Cyclobutane-1,1-diyldimethanol

HCID 178479937CID 28556

생성물 1

HCID 11186355[1-({[5-(4-chlorophenyl)-1-methyl-1H-imidazol-2-yl]sulfanyl}methyl)cyclobutyl]methanol

실험 절차

The title compound was prepared using the same experimental procedure as in example 19a from [1-(hydroxymethyl)cyclobutyl]methanol and 5-(4-chlorophenyl)-1-methyl-1H-imidazole-2-thiol. 1H NMR (300 MHz, CDCl3) δ 7.41-7.25 (m, 5H), 3.62 (s, 2H), 3.49 (s, 3H), 3.46 (s, 2H), 2.04-1.63 (m, 6H).

출처 및 근거

ORD 기록: ord-18b55d116dde4613af199cb523e17255
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07282512B2

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