L-Alanine 1,1-dimethylethyl ester → tert-Butyl(2S)-2-(3-azido-2-oxopyrrolidin-1-yl)propanoate

반응식

[N:1]([CH:4]([CH2:10][CH2:11]I)[C:5](OCC)=[O:6])=[N+:2]=[N-:3].[C:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])([CH3:16])([CH3:15])[CH3:14]>>[N:1]([CH:4]1[CH2:10][CH2:11][N:20]([C@@H:19]([CH3:21])[C:18]([O:17][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:22])[C:5]1=[O:6])=[N+:2]=[N-:3]

참가 물질

반응물 2

HCID 89016L-Alanine 1,1-dimethylethyl ester

HCID 22017145Ethyl 2-azido-4-iodobutanoate

생성물 1

HCID 86593859tert-Butyl(2S)-2-(3-azido-2-oxopyrrolidin-1-yl)propanoate

실험 절차

Using ethyl 2-azido-4-iodobutanoate and L-alanine tert-butyl ester, and the procedure described for Intermediate 33, the title compound was prepared as a mixture of two diastereoisomers.

출처 및 근거

ORD 기록: ord-387a547c4414482cb0bdd1843ef7fbc8
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07282497B2

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