5-Chloro-1-benzofuran-2-carboxylic acid → 5-Chloro-1-benzofuran

HRID 1180984

반응식

HRID 1180984 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](C(O)=O)=[CH:7][C:6]=2[CH:13]=1>CN1CCCC1=O.[Cu]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:13]=1

참가 물질

4

반응물 1

HCID 9378385-Chloro-1-benzofuran-2-carboxylic acid

생성물 1

HCID 900135-Chloro-1-benzofuran수율 418.7%

시약·촉매·용매 2

HCID 23978Copper촉매HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
250 °C

실험 절차

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.

후처리

  1. temperatureThe reaction vessel was cooled to room temperature
  2. customthe combined mixtures partitioned between water and diethyl ether
  3. washThe organic layer was washed with water and brine
  4. dry with materialdried (over magnesium sulphate)
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3a74ec20bc7548b99a9b7da5d2fc7c7a
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07282497B2

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