Aluminium lithium hydride → N9-phenethyl-8-hydroxymethyladenine
반응식
[CH2:1]([N:9]1[C:17]([C:18](OC)=[O:19])=[N:16][C:15]2[C:10]1=[N:11][CH:12]=[N:13][C:14]=2[NH2:22])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([N:9]1[C:17]([CH2:18][OH:19])=[N:16][C:15]2[C:10]1=[N:11][CH:12]=[N:13][C:14]=2[NH2:22])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1참가 물질
4
실험 절차
A solution of N9-phenethyl-8-methoxycarbonyladenine (1 mmol) in tetrahydrofuran was treated with lithium aluminum hydride (1 mmol) at 0° C. for 1 h. Extraction and chromatography gave N9-phenethyl-8-hydroxymethyl-adenine as a white solid. TLC: Rf=0.31, 10% MeOH—CH2Cl2.
후처리
- extractionExtraction and chromatography
출처 및 근거
- ORD 기록
- ord-ca59b78df4b54ff7aae5624bb505f4b7
- 출처 데이터셋
- uspto-grants-2007_10
- 특허 번호
- US07285543B2
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