Lithium borohydride → HCID 58980888, 화합물

HRID 1181366노트

반응식

HRID 1181366 반응식
[F:1][C@@H:2]1[CH2:6][N:5]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[C@H:4]([C:14](OC)=[O:15])[CH2:3]1.[Li+].[BH4-]>C1COCC1>[F:1][C@@H:2]1[CH2:6][N:5]([C:7]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:8])[C@H:4]([CH2:14][OH:15])[CH2:3]1

참가 물질

4

반응물 2

HCID 4148881Lithium borohydrideHCID 10977773(2S,4S)-1-Tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate

생성물 1

HCID 58980888HCID 58980888, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a THF (20 mL) solution of 1-tert-butyl 2-methyl (2S,4S)-4-fluoro-1,2-pyrrolidinedicarboxylate (950 mg, 3.9 mmol) at 0° C., 5.8 mL 2M LiBH4 (11.6 mmol, 3 eq) was added slowly. The resulting mixture was left stirring overnight while allowing the temperature to warm up to room temperature.

후처리

  1. waitThe resulting mixture was left

출처 및 근거

ORD 기록
ord-d8c9b8b67ee840b0a60d53dcc3ca815d
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285557B2

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