Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pivalic acid → 2-(tert-Butyl)isonicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pivalic acid | HCID 6417 | — |
| 반응물 | 4-Cyanopyridine | HCID 7506 | — |
| 반응물 | Ammonium Persulfate | HCID 62648 | — |
| 촉매 | Silver Nitrate | HCID 24470 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 2-(tert-Butyl)isonicotinonitrile | HCID 693322 | 42.3% |
반응 단계
A mixture of 4-cyanopyridine (10 g, 96 mmol), trimethylacetic acid (9.8 g, 96 mmol), and silver nitrate (1.63 g, 9.6 mmol) in 10% aqueous sulfuric acid (100 ml) at 70° C. was treated with a solution of ammonium peroxodisulfate (21.9 g, 96 mmol) in water (120 ml) according to the method of Description 10. Purification by column chromatography on silica eluting with 10% Et2O in iso-hexanes gave the title compound (6.5 g, 42%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07285563B2 |
| 출처 데이터셋 | uspto-grants-2007_10 |
| ORD ID | ord-7ba1e8b2858940a5a20c6df8d7312dd5 |
| 출처 메모 | uspto-grants-2007_10 |