Ammonia → 1-(2-Benzyl-1,3-thiazol-4-yl)methanamine

HRID 1181397노트

반응식

HRID 1181397 반응식
[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13]Cl)[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:15]>>[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13][NH2:15])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 30158742-Benzyl-4-chloromethylthiazole

생성물 1

HCID 209828961-(2-Benzyl-1,3-thiazol-4-yl)methanamine수율 50%

실험 절차

2-Benzyl-4-chloromethylthiazole [Pharmazie 1972, 27, 146] (223.7 g, 1 mol) was stirred with liquid ammonia (600 ml) in an autoclave for 24 hours. The ammonia was removed and the product was distilled in vacuo [bp (0.02 mmHg) 141-144° C.] to give the title compound (102 g, 50%).

후처리

  1. customThe ammonia was removed
  2. distillationthe product was distilled in vacuo [bp (0.02 mmHg) 141-144° C.]

출처 및 근거

ORD 기록
ord-57c04ec346d14abe86301c57106f7f6a
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285563B2

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