Ammonia → 8-Fluoroisoquinoline

HRID 1181401노트

반응식

HRID 1181401 반응식
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]#[C:11][Si](C)(C)C)[C:3]=1[CH:4]=O.CO.[NH3:18]>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:3]=1[CH:4]=[N:18][CH:11]=[CH:10]2

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 887MethanolHCID 59536255HCID 59536255, 화합물

생성물 1

HCID 269856658-Fluoroisoquinoline수율 58%

반응 조건

온도
80 °C

실험 절차

2-Fluoro-6-[(trimethylsilyl)ethynyl]benzaldehyde Description 40; 10.38 g, 47.1 mmol) was dissolved in 2M ammonia in methanol (235 ml, 471 mmol) in a Parr flask and the resulting mixture heated at 80° C. with shaking on a Parr apparatus (ca. 35 psi achieved). The reaction was cooled and the solvents evaporated. The residue was purified by column chromatography on silica eluting with a gradient from neat dichloromethane to 2% methanol in dichloromethane to give the title compound (4.0 g, 58%).

후처리

  1. temperatureThe reaction was cooled
  2. customthe solvents evaporated
  3. customThe residue was purified by column chromatography on silica eluting with a gradient from neat dichloromethane to 2% methanol in dichloromethane

출처 및 근거

ORD 기록
ord-11f02a3e3da14eae86d5fe3bbf3b0a67
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285563B2

반응 노트

불러오는 중…