Water → 2-Methoxy-4-(trifluoromethyl)benzonitrile

HRID 1181424

반응식

HRID 1181424 반응식
[N+]([C:4]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7])([O-])=O.[CH3:16][O-:17].[Na+].O>CO>[CH3:16][O:17][C:4]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

참가 물질

5

반응물 3

HCID 962WaterHCID 699022-Nitro-4-(trifluoromethyl)benzonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 190013762-Methoxy-4-(trifluoromethyl)benzonitrile수율 91%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 2-nitro-4-(trifluoromethyl)benzonitrile (22.48 g, 104 mmol) in anhydrous methanol (110 ml) was added dropwise 25% sodium methoxide in methanol (24.72 ml, 114.4 mmol), and the resulting mixture stirred at room temperature for 1 hour. Water (110 ml) was added and the resulting solids collected by filtration. The solids were dissolved in DCM (150 ml), washed with sat NaCl (75 ml), dried over Na2SO4, filtered and evaporated to give the title compound (19 g, 91%) as a white solid.

후처리

  1. filtrationthe resulting solids collected by filtration
  2. dissolutionThe solids were dissolved in DCM (150 ml)
  3. washwashed with sat NaCl (75 ml)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-c429fac802f345ae93bd22b24c07a7e3
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285563B2

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