Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4-((Morpholin-4-yl)methyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-((Morpholin-4-yl)methyl)benzonitrile | HCID 216864 | 68% |
반응 단계
To a solution of 4-cyanobenzylbromide (1.0 g, 5.1 mmol) in MeCN (10 ml) was added morpholine (0.44 g, 0.44 ml, 5.1 mmol) and the reaction was stirred at room temperature for 1 h. The precipitate was filtered off and partioned between CH2Cl2 and NaOH (2M). The organic layer was separated, dried over MgSO4 and dried to give the desired nitrile (0.70 g, 68%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07285563B2 |
| 출처 데이터셋 | uspto-grants-2007_10 |
| ORD ID | ord-c03e08bb546d4897940e0340369484ed |
| 출처 메모 | uspto-grants-2007_10 |