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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 7-Isobutyl-5-(2-morpholin-4-ylethyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181685
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HRID 1181685 반응식
Cl.Cl[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.C1CCN2C(=NCCC2)CC1.[CH2:22]([N:26]1[C:31]2=[N:32][N:33]([CH2:41][C:42]3[C:51]4[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=4)[CH:45]=[CH:44][CH:43]=3)[C:34]([C:35]3[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=3)=[C:30]2[C:29](=[O:52])[NH:28][C:27]1=[O:53])[CH:23]([CH3:25])[CH3:24]>CN(C)C=O>[CH2:22]([N:26]1[C:31]2=[N:32][N:33]([CH2:41][C:42]3[C:51]4[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=4)[CH:45]=[CH:44][CH:43]=3)[C:34]([C:35]3[CH:36]=[CH:37][N:38]=[CH:39][CH:40]=3)=[C:30]2[C:29](=[O:52])[N:28]([CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][O:8][CH2:7][CH2:6]2)[C:27]1=[O:53])[CH:23]([CH3:25])[CH3:24]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 694274457-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

생성물 1

HCID 589809147-Isobutyl-5-(2-morpholin-4-ylethyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione수율 91.1%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

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온도
80 °C

실험 절차

4-(2-chloroethyl)morpholine hydrochloride (0.0435 g) followed by DBU (0.094 g) were added to a solution of 7-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (0.0668 g) in dimethylformamide (1 ml). The mixture was heated at 80° C. for 18 hours then cooled to room temperature. The crude reaction was purified on preparative HPLC to give the title compound (0.077 g). Mass: 538.90 (M+H).

후처리

  1. temperaturethen cooled to room temperature
  2. customThe crude reaction
  3. customwas purified on preparative HPLC

출처 및 근거

ORD 기록
ord-f253712b955c4370ae2ee2831182f521
출처 데이터셋
uspto-grants-2007_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07285558B2

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