3-Formyl-1H-indole-5-carbonitrile → 3-{[7-isobutyl-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl]methyl}-1H-indole-5-carbonitrile

HRID 1181757

반응식

HRID 1181757 반응식
[NH:1]([C:3]1[N:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7](=[O:13])[N:6]([CH3:14])[C:5](=[O:15])[CH:4]=1)[NH2:2].[CH:16]([C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([C:27]#[N:28])[CH:25]=2)[NH:20][CH:19]=1)=O.[CH3:29][N:30]1[CH:34]=[CH:33][N:32]=[C:31]1[CH:35]=O>>[CH2:9]([N:8]1[C:3]2=[N:1][N:2]([CH2:16][C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([C:27]#[N:28])[CH:25]=4)[NH:20][CH:19]=3)[C:35]([C:31]3[N:30]([CH3:29])[CH:34]=[CH:33][N:32]=3)=[C:4]2[C:5](=[O:15])[N:6]([CH3:14])[C:7]1=[O:13])[CH:10]([CH3:11])[CH3:12]

참가 물질

4

반응물 3

HCID 285043-Formyl-1H-indole-5-carbonitrileHCID 1395751-Methyl-2-imidazolecarboxaldehydeHCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 589809433-{[7-isobutyl-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl]methyl}-1H-indole-5-carbonitrile

실험 절차

This compound was made following the procedure described above, starting with 6-hydrazino-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first with 3-formyl-1H-indole-5-carbonitrile, followed by 1-methyl-1H-imidazole-2-carbaldehyde. Mass: 457.14 (M+H).

출처 및 근거

ORD 기록
ord-fbfe4740898148bb99670dda9b7533de
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285558B2

연결된 노트

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