Potassium Carbonate → 2-[(5-chloro-1H-indol-3-yl)methyl]-7-(cyclobutylmethyl)-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181768노트

반응식

HRID 1181768 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][N:12]1[C:20]([C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[C:19]2[C:14]([NH:15][C:16](=[O:29])[N:17]([CH3:28])[C:18]2=[O:27])=[N:13]1.Br[CH2:31][CH:32]1[CH2:35][CH2:34][CH2:33]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][N:12]1[C:20]([C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[C:19]2[C:14]([N:15]([CH2:31][CH:32]3[CH2:35][CH2:34][CH2:33]3)[C:16](=[O:29])[N:17]([CH3:28])[C:18]2=[O:27])=[N:13]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 2734658(Bromomethyl)cyclobutaneHCID 1363341142-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

생성물 1

HCID 589811672-[(5-chloro-1H-indol-3-yl)methyl]-7-(cyclobutylmethyl)-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

This compound was synthesized by the reaction of 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione and (bromomethyl)cyclobutane using potassium carbonate as a base in DMF at 80° C. Mass: 478.16 (M+H).

후처리

  1. customat 80° C

출처 및 근거

ORD 기록
ord-d8e507d0ce104cb3a24dff164a6fac6f
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285558B2

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