6-Chloroquinoline-4-carbaldehyde → 2-[(6-chloroquinolin-4-yl)methyl]-7-isobutyl-3-(4-methyl-4H-1,2,4-triazol-3-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181837노트

반응식

HRID 1181837 반응식
[NH:1]([C:3]1[N:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7](=[O:13])[NH:6][C:5](=[O:14])[CH:4]=1)[NH2:2].[Cl:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][CH:20]=[C:19]2[CH:26]=O.[CH3:28][N:29]1[CH:33]=[N:32][N:31]=[C:30]1[CH:34]=O>>[Cl:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][CH:20]=[C:19]2[CH2:26][N:2]1[C:34]([C:30]2[N:29]([CH3:28])[CH:33]=[N:32][N:31]=2)=[C:4]2[C:3]([N:8]([CH2:9][CH:10]([CH3:11])[CH3:12])[C:7](=[O:13])[NH:6][C:5]2=[O:14])=[N:1]1

참가 물질

4

반응물 3

HCID 31460316-Chloroquinoline-4-carbaldehydeHCID 157078954-methyl-4H-1,2,4-triazole-3-carbaldehydeHCID 694280776-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 589810832-[(6-chloroquinolin-4-yl)methyl]-7-isobutyl-3-(4-methyl-4H-1,2,4-triazol-3-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

실험 절차

This compound was made following the procedure described above, starting with 6-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione, and condensing first with 6-chloroquinoline-4-carbaldehyde, followed by 4-methyl-4H-1,2,4-triazole-3-carbaldehyde. 460.2 (M+H).

출처 및 근거

ORD 기록
ord-22b6767e484149e09c84a3e33a57bf01
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285558B2

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