Trifluoroacetic acid → N-(Toluene-4-sulfonyl)-L-prolyl-L-asparagine

HRID 1182036노트

반응식

HRID 1182036 반응식
O.[C:2]1([CH3:19])[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:18][CH2:17][CH2:16][C@H:12]2[C:13]([OH:15])=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl.C([O:25][C:26](=[O:33])[C@H:27]([CH2:29][C:30](=[O:32])[NH2:31])[NH2:28])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[C:2]1([CH3:19])[CH:3]=[CH:4][C:5]([S:8]([N:11]2[CH2:18][CH2:17][CH2:16][C@H:12]2[C:13]([NH:28][C@H:27]([C:26]([OH:33])=[O:25])[CH2:29][C:30](=[O:32])[NH2:31])=[O:15])(=[O:9])=[O:10])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 16218498tert-Butyl L-asparaginate--hydrogen chloride (1/1)HCID 69463844N-tosyl-(s)-proline monohydrate

생성물 1

HCID 9951963N-(Toluene-4-sulfonyl)-L-prolyl-L-asparagine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to L-asparagine tert-butyl ester hydrochloride using the procedure described in Method 3. The title compound was prepared, via cleavage of the tert-butyl ester using trifluoroacetic acid in CH2Cl2, to provide a solid, mp=178-180° C.

후처리

  1. customto provide a solid, mp=178-180° C.

출처 및 근거

ORD 기록
ord-d80676c15169475f9e5fe544ce8a5fdd
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07288526B2

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