Bromine → 6-Amino-5-bromopyridine-3-carbonitrile

HRID 1182051

반응식

HRID 1182051 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[Br:10]Br>CC(O)=O>[NH2:1][C:2]1[C:9]([Br:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 8182602-Amino-5-cyanopyridine

생성물 1

HCID 14912506-Amino-5-bromopyridine-3-carbonitrile수율 65%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

To a solution of 6-Amino-nicotinonitrile (102 mg, 0.86 mmol) in AcOH (2 mL) add a solution of Br2 1.0M in AcOH (0.86 mmol). Stir the mixture at room temperature for 2 hours. Eliminate the solvent. Purify by flash chromatography on silica gel (eluent: hexane/EtOAc 3/1) to afford the title compound (110 mg, 65%).

후처리

  1. customPurify by flash chromatography on silica gel (eluent: hexane/EtOAc 3/1)

출처 및 근거

ORD 기록
ord-ac0583a72f1347ac9f35ec47af184ec0
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07288543B2

연결된 노트

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