Trifluoroacetic acid → 3-(3-(4-Chlorobenzyl)azetidin-1-yl)propan-1-amine

HRID 1182100

반응식

HRID 1182100 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:14][CH:13]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH2:12]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][CH:13]2[CH2:14][N:11]([CH2:10][CH2:9][CH2:8][NH2:7])[CH2:12]2)=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69411053{3-[3-(4-Chloro-benzyl)-azetidin-1-yl]-propyl}carbamic acid tert-butyl ester

생성물 1

HCID 694091233-(3-(4-Chlorobenzyl)azetidin-1-yl)propan-1-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of {3-[3-(4-chloro-benzyl)-azetidin-1-yl]-propyl}-carbamic acid tert-butyl ester (0.48 g, 1.43 mmol) in DCM (5 ml) is treated with trifluoroacetic acid (2 ml) and the reaction mixture stirred for 1.25 hours. The solvent is evaporated and the crude product partitioned between 1 M sodium hydroxide solution and 20% isopropanol in DCM. The organic phase is evaporated to afford 3-[3-(4-chloro-benzyl)-azetidin-1-yl]-propylamine. [M+H] 239.13.

후처리

  1. customThe solvent is evaporated
  2. customthe crude product partitioned between 1 M sodium hydroxide solution and 20% isopropanol in DCM
  3. customThe organic phase is evaporated

출처 및 근거

ORD 기록
ord-30d854ffd4d44fbcabb1be1be1dc836c
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07288537B2

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