Pyridine → HCID 69359775, 화합물

HRID 1182117노트

반응식

HRID 1182117 반응식
[CH2:1]([N:3]1[N:7]=[N:6][C:5]([NH2:8])=[N:4]1)[CH3:2].N1C=CC=CC=1.[C:15]1([O:21][C:22](Cl)=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1COCC1>[C:15]1([O:21][C:22](=[O:23])[NH:8][C:5]2[N:6]=[N:7][N:3]([CH2:1][CH3:2])[N:4]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 42745882-ethyl-2H-tetrazol-5-amine

생성물 1

HCID 69359775HCID 69359775, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 2-ethyl-2H-tetrazol-5-ylamine (0.1 g, 0.88 mmol) in dry THF (2 ml) is treated with pyridine (0.09 ml, 1.10 mmol) followed by a solution of phenylchloroformate (0.11 ml, 0.911 mmol) in THF (1 ml). The reaction mixture is stirred at ambient temperature for 1.5 hours, then partitioned between ethylacetate and water. The ethylacetate phase is dried over magnesium sulphate and evaporated to afford (2-Ethyl-2H-tetrazol-5-yl)-carbamic acid phenyl ester as a white solid. 1H NMR (CDCl3, 400 MHz) δ, 7.90 (1H, brs), 7.30 (2H, m), 7.15, (3H, m), 4.60 (2H, q) 1.60 (3H, t).

후처리

  1. custompartitioned between ethylacetate and water
  2. dry with materialThe ethylacetate phase is dried over magnesium sulphate
  3. customevaporated

출처 및 근거

ORD 기록
ord-472be5302cae42c9a20a401a9028f0c1
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07288537B2

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