Triethylamine → (3S,4S)-3-[2-(4-Methoxy-benzyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-ylmethyl]-4-phenyl-pyrrolidine-1-carboxylic Acid Tert-Butyl Ester

HRID 1182168노트

반응식

HRID 1182168 반응식
Cl.[CH3:2][O:3][C:4]1[CH:21]=[CH:20][C:7]([CH2:8][N:9]2[CH2:13][CH2:12][C:11]3([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:10]2=[O:19])=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:29]([O:33][C:34]([N:36]1[CH2:40][C@H:39]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C@@H:38]([CH:47]=O)[CH2:37]1)=[O:35])([CH3:32])([CH3:31])[CH3:30].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[C:29]([O:33][C:34]([N:36]1[CH2:40][C@H:39]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C@@H:38]([CH2:47][N:16]2[CH2:15][CH2:14][C:11]3([C:10](=[O:19])[N:9]([CH2:8][C:7]4[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:21][CH:20]=4)[CH2:13][CH2:12]3)[CH2:18][CH2:17]2)[CH2:37]1)=[O:35])([CH3:32])([CH3:30])[CH3:31]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 5049666Sodium triacetoxyborohydrideHCID 450741222,8-Diazaspiro[4.5]decan-1-one, 2-[(4-methoxyphenyl)methyl]-, (Hydrochloride) (1:1)HCID 58981949(3R,4S)-3-formyl-4-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 11284019(3S,4S)-3-[2-(4-Methoxy-benzyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-ylmethyl]-4-phenyl-pyrrolidine-1-carboxylic Acid Tert-Butyl Ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To 3.41 g of 2-(4-methoxy-benzyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride (12.3 mmol) in dichloromethane (50 mL) was added triethylamine (1.71 mL, 12.3 mmol) followed by 3.85 g of (3R,4S)-3-formyl-4-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester (12.3 mmol) in dichloromethane (75 mL) and stirred for 1 h at room temperature. Sodium triacetoxyborohydride (3.91 g, 18.4 mmol) was then added and the reaction mixture stirred overnight at room temperature.

후처리

  1. stirringthe reaction mixture stirred overnight at room temperature

출처 및 근거

ORD 기록
ord-cc007023722e4e78b65d7da5bc0be681
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07288548B2

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