Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine hydrochloride → 4-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine hydrochloride | HCID 11130 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one | HCID 135850831 | — |
| 생성물 | 4-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline | HCID 21939237 | 89% |
반응 단계
Prepared from 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one (1.0 g, 3.12 mmol), triethylamine hydrochloride (472 mg, 3.43 mmol), and POCl3. Purification by flash chromatography afforded a white solid (89% yield). HPLC-Method A, Rt 4.10 min, (98%), MS (m/z) 258.08 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098330B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-b134537bc4c643eabbfe65a48bec7bec |
| 출처 메모 | uspto-grants-2006_08 |