Pivaloyl chloride → 2-Bromo-2,2-difluoroethyl pivalate
반응식
FC(F)(S([O-])(=O)=O)CO.BrC(F)(F)C(OCC)=O.[Br:19][C:20]([F:24])([F:23])[CH2:21][OH:22].[C:25](Cl)(=[O:30])[C:26]([CH3:29])([CH3:28])[CH3:27]>>[C:25]([O:22][CH2:21][C:20]([Br:19])([F:24])[F:23])(=[O:30])[C:26]([CH3:29])([CH3:28])[CH3:27]참가 물질
실험 절차
On the other hand, the 1,1-difluoro-2-hydroxyethanesulfonate of the general formula (17) can be prepared by reducing ethyl bromodifluoroacetate to 2-bromo-2,2-difluoroethanol, esterifying the 2-bromo-2,2-difluoroethanol with pivaloyl chloride to form 2-bromo-2,2-difluoroethyl pivalate, sulfinating the 2-bromo-2,2-difluoroethyl pivalate to form 1,1-difluoro-2-(pivaloyloxy)ethanesulfinate, oxidizing the 1,1-difluoro-2-(pivaloyloxy)ethanesulfinate to 1,1-difluoro-2-(pivaloyloxy)ethanesulfonate, and then, saponifying the 1,1-difluoro-2-(pivaloyloxy)ethanesulfonate. Any known esterification technique can be adopted to react the carboxylic acid derivative of the general formula (16) and the 1,1-difluoro-2-hydroxyethanesulfonate of the general formula (17) for production of the polymerizable fluorine-containing sulfonate compound of the general formula (3) as indicated in SCHEME (1).
출처 및 근거
- ORD 기록
- ord-0457debc529d4e0da241829e75df0a04
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08663897B2
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