Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-butyl-5-((4-(trifluoromethyl)pyridin-3-yl)methylamino)isoindolin-1-one TFA
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-(Trifluoromethyl)pyridine-3-carbaldehyde | HCID 21354724 | — |
| 반응물 | 5-Amino-2-butyl-2,3-dihydro-1H-isoindol-1-one | HCID 67432065 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-butyl-5-((4-(trifluoromethyl)pyridin-3-yl)methylamino)isoindolin-1-one TFA | HCID 86762286 | 19% |
반응 단계
5-amino-2-butylisoindolin-1-one (35.0 mg, 0.17 mmol), ZnCl2 (14.0 mg, 0.10 mmol) and NaCNBH4 (12.9 mg, 0.21 mmol) were consecutively added to a solution of 4-(trifluoromethyl)nicotinaldehyde (30.0 mg, 0.17 mmol) in MeOH (4 mL). After stirring overnight at room temperature excess water was added. The reaction mixture was extracted with EtOAc, the combined org. layers were washed with water, dried (MgSO4) and the solvent was removed in vacuo. Purification by HPLC provided 2-butyl-5-((4-(trifluoromethyl)pyridin-3-yl)methylamino)isoindolin-1-one TFA (16.0 mg, 19%). ESI-MS [M+H]+=364.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08664214B2 |
| 출처 데이터셋 | uspto-grants-2014_03 |
| ORD ID | ord-dafe9df8dd884e4aae5de41dfe250f89 |
| 출처 메모 | uspto-grants-2014_03 |