Sodium ethoxide → 3-amino-6-bromo-4-fluoro-1H-indole-2-carboxylic acid amide
반응식
[Br:1][C:2]1[CH:3]=[C:4]([F:15])[C:5]([C:13]#[N:14])=[C:6]([NH:8][CH2:9][C:10]([NH2:12])=[O:11])[CH:7]=1.CC[O-].[Na+]>CC(O)C>[NH2:14][C:13]1[C:5]2[C:6](=[CH:7][C:2]([Br:1])=[CH:3][C:4]=2[F:15])[NH:8][C:9]=1[C:10]([NH2:12])=[O:11]참가 물질
4
실험 절차
17.3 g (63.6 mmol) 2-(5-bromo-2-cyano-3-fluorophenylamino)acetamide was suspended in 150 ml 2-propanol and, after the addition of 10 ml NaOEt solution (21% in EtOH), the suspension was refluxed for 14 h. Having cooled down to room temperature, the solvent was concentrated and water was added. The resulting precipitate was sucked off and washed with water. 15.4 g (89%) 3-amino-6-bromo-4-fluoro-1H-indole-2-carboxylic acid amide was obtained. ESI-MS [m/z]: 272, 274 [M+H]+
후처리
- temperaturethe suspension was refluxed for 14 h
- concentrationthe solvent was concentrated
- additionwater was added
- washwashed with water
출처 및 근거
- ORD 기록
- ord-fe1d13a228ea46db9b291b37477cd410
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08664233B2
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