[1-(4'-{4-[(E)-4-(4-Benzyl-phenyl)-1-hydroxy-but-3-enyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester → [1-(4'-{4-[4-(4-Benzyl-phenyl)-1-hydroxy-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

HRID 1183330노트

반응식

HRID 1183330 반응식
[CH2:1]([O:3][C:4](=[O:45])[CH2:5][C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH:27]([OH:44])[CH2:28]/[CH:29]=[CH:30]/[C:31]4[CH:36]=[CH:35][C:34]([CH2:37][C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)=[CH:33][CH:32]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:45])[CH2:5][C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH:27]([OH:44])[CH2:28][CH2:29][CH2:30][C:31]4[CH:36]=[CH:35][C:34]([CH2:37][C:38]5[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=5)=[CH:33][CH:32]=4)=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)[CH3:2]

참가 물질

4

반응물 1

HCID 66581235[1-(4'-{4-[(E)-4-(4-Benzyl-phenyl)-1-hydroxy-but-3-enyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

생성물 1

HCID 66577652[1-(4'-{4-[4-(4-Benzyl-phenyl)-1-hydroxy-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

[1-(4′-{4-[(E)-4-(4-Benzyl-phenyl)-1-hydroxy-but-3-enyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester (0.203 g, 0.340 mmol) was dissolved in EtOH and palladium on carbon (0.020 g, 10% wt., wet: 50% w/w H2O) was added. The reaction was stirred under H2 (g) atmosphere overnight then filtered through Celite to afford the title compound in EtOH solution, which was brought to the next step without further purification.

후처리

  1. filtrationthen filtered through Celite

출처 및 근거

ORD 기록
ord-6ce1e928f1c84a6db52c566d44272fb6
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08664220B2

반응 노트

불러오는 중…