참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (3-Bromophenyl)(phenyl)methanol | HCID 285827 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Benzyl-3-bromobenzene | HCID 597532 | — |
반응 단계
(3-Bromo-phenyl)-phenyl-methanol (from previous step) was dissolved in diethyl ether (10 mL) and the solution was added dropwise to a suspension of lithium aluminum hydride (0.607 g, 16 mmol) and aluminum chloride (2.11 g, 16 mmol) stirring in THF (15 mL). The reaction was heated to 40° C. for 1 hour then cooled to 0° C., quenched with H2O, and submitted to standard aqueous workup. The crude product was purified via silica gel chromatography (0-5% EtOAc in hexanes) to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08664220B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_03 |
|---|
| ORD ID | ord-09d92103cc3145faa05c373ed253a4df |
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| 출처 메모 | uspto-grants-2014_03 |
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