Ammonia → tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

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[CH:1]1([C:11]([O:13]CC)=O)[CH2:5][CH2:4][CH2:3][CH:2]1[C:6](OCC)=[O:7].[NH3:16]>>[C:6]1(=[O:7])[CH:2]2[CH2:3][CH2:4][CH2:5][CH:1]2[C:11](=[O:13])[NH:16]1

참가 물질

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HCID 222Ammonia

HCID 3021700Diethyl cyclopentane-1,2-dicarboxylate

생성물 1

HCID 110709tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione수율 96%

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온도: 130 °C

실험 절차

Load 1 kg of diethyl 1,2-cyclopentanedicarboxylate and 1.02 kg of 27% ammonia into an autoclave. The reaction mixture is heated in the autoclave at a temperature of 130° C. for a minimum of 4 hours. After cooling to 60° C. and depressurisation, evaporation of the solvent is carried out. The residue is then subjected to pyrolysis at 280° C. for 1 hour. The imide is purified by distillation in vacuo (4-12 mbars) at a temperature of 200° C. After isolation, the title product is obtained in a yield of 96%.

후처리

temperatureAfter cooling to 60° C.
customdepressurisation, evaporation of the solvent
distillationThe imide is purified by distillation in vacuo (4-12 mbars) at a temperature of 200° C

출처 및 근거

ORD 기록: ord-4a96273e15254919994c22d722200980
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08664408B2

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