2-Bromoanthraquinone → 2-Bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol

HRID 1184047

반응식

HRID 1184047 반응식
[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12](=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:17])[C:4]=2[CH:3]=1.[C:18]1([Li])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O1CCCC1>[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)([OH:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([C:2]3[CH:15]=[CH:14][CH:13]=[CH:4][CH:3]=3)([OH:17])[C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 2210132-BromoanthraquinoneHCID 178506676HCID 178506676, 화합물

생성물 1

HCID 231602182-Bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4.9 g (17 mmol) of 2-bromo-9,10-anthraquinone was put into a 300 mL three-neck flask. The atmosphere in the flask was substituted with nitrogen. 100 mL of tetrahydrofuran (THF) was added and dissolved well. After that, 18 mL (37 mmol) of phenyl lithium was dripped into the solution, and the mixture was stirred at room temperature for about 12 hours. After the reaction, the solution was washed with water. Then, the aqueous layer was extracted with ethyl acetate. The extracted solution and an organic layer were mixed to be dried with magnesium sulfate. After the drying, this mixture was suction-filtrated and the filtrate was concentrated, so that 2-bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol (about 7.6 g), which was an object, was obtained.

후처리

  1. dissolutiondissolved well
  2. customAfter the reaction
  3. washthe solution was washed with water
  4. extractionThen, the aqueous layer was extracted with ethyl acetate
  5. additionThe extracted solution and an organic layer were mixed
  6. dry with materialto be dried with magnesium sulfate
  7. filtrationAfter the drying, this mixture was suction-filtrated
  8. concentrationthe filtrate was concentrated, so that 2-bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol (about 7.6 g), which
  9. customwas obtained

출처 및 근거

ORD 기록
ord-ec92f668748148c5a9015fd1c2a9dca0
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08664849B2

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