3-fluoro-N-(4-methoxybutyl)-2-nitroaniline → 6-Fluoro-2-(4-methoxybutylamino)aniline

HRID 1184131노트

반응식

HRID 1184131 반응식
[F:1][C:2]1[C:3]([N+:15]([O-])=O)=[C:4]([CH:12]=[CH:13][CH:14]=1)[NH:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][CH3:11]>CO.[C].[Pd]>[F:1][C:2]1[C:3]([NH2:15])=[C:4]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][CH3:11])[CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 1

HCID 583554133-fluoro-N-(4-methoxybutyl)-2-nitroaniline

생성물 1

HCID 583552296-Fluoro-2-(4-methoxybutylamino)aniline수율 100%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

3-Fluoro-N-(4-methoxybutyl)-2-nitroaniline (2.90 g) was dissolved in methanol (50 ml), palladium-carbon (5%, 230 mg) was added, and the mixture was stirred for 3 hr under a hydrogen atmosphere. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to give the object product (2.54 g).

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e771aee59e694b788457585951fd3414
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08664380B2

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