6-Bromo-N-methylnicotinamide → HCID 67976639, 화합물

HRID 1184748노트

반응식

HRID 1184748 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[CH2:18][C:17]3[CH:19]=[C:20](B4OC(C)(C)C(C)(C)O4)[CH:21]=[CH:22][C:16]=3[O:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:33]1[CH:42]=[CH:41][C:36]([C:37]([NH:39][CH3:40])=[O:38])=[CH:35][N:34]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH:14]2[CH2:18][C:17]3[CH:19]=[C:20]([C:33]4[CH:42]=[CH:41][C:36]([C:37](=[O:38])[NH:39][CH3:40])=[CH:35][N:34]=4)[CH:21]=[CH:22][C:16]=3[O:15]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 230921426-Bromo-N-methylnicotinamideHCID 679736294-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 67976639HCID 67976639, 화합물

실험 절차

The title compound is prepared from 4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester and 6-bromo-N-methylnicotinamide following a procedure analogous to that described in Example 1. LC (method 10): tR=1.69 min; Mass spectrum (ESI+): m/z=438 [M+H]+.

출처 및 근거

ORD 기록
ord-fd0495a270bb48639b0e035f0e2e61a2
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08669271B2

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