4-Bromopyridazine hydrobromide → 4-(5-Pyridazin-4-yl-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

HRID 1184756

반응식

HRID 1184756 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[CH2:18][C:17]3[CH:19]=[C:20](B4OC(C)(C)C(C)(C)O4)[CH:21]=[CH:22][C:16]=3[O:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br.Br[C:34]1[CH:39]=[CH:38][N:37]=[N:36][CH:35]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH:14]2[CH2:18][C:17]3[CH:19]=[C:20]([C:34]4[CH:39]=[CH:38][N:37]=[N:36][CH:35]=4)[CH:21]=[CH:22][C:16]=3[O:15]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 534079064-Bromopyridazine hydrobromideHCID 679736294-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 679902134-(5-Pyridazin-4-yl-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

실험 절차

The title compound is prepared from 4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester and 4-bromopyridazine hydrobromide following a procedure analogous to that described in Example 1. LC (method 6): tR=1.19 min; Mass spectrum (ESI+): m/z=382 [M+H]+.

출처 및 근거

ORD 기록
ord-3b7cadd347784a339a74745d65af36d1
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08669271B2

연결된 노트

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