tert-Butyl (4-methyl-3-nitrophenyl)carbamate → 5-(Boc-amino)-2-methylaniline

HRID 1184837노트

반응식

HRID 1184837 반응식
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([N+:15]([O-])=O)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([NH2:15])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 18954623tert-Butyl (4-methyl-3-nitrophenyl)carbamate

생성물 1

HCID 246997865-(Boc-amino)-2-methylaniline수율 96.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

10% palladium on charcoal (6 g) was added to a solution of (4-methyl-3-nitro-phenyl)-carbamic acid tert-butyl ester 26 (60 g, 238 mmol) in ethanol (1200 mL). The mixture was hydrogenated at atmospheric pressure at room temperature for 18 h. The palladium catalyst was removed by filtration over celite and the solvent was removed by evaporation to give (3-Amino-4-methyl-phenyl)-carbamic acid tert-butyl ester 27 (51 g, 96%).

후처리

  1. customThe palladium catalyst was removed by filtration over celite
  2. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-f2c75e4c4dce4a608de3c7a36308b3b2
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08669256B2

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