Methyl 5-(2,4-dimethoxybenzylamino)-4-nitrothiophene-2-carboxylate → Methyl 5-amino-4-nitrothiophene-2-carboxylate
반응식
COC1C=C(OC)C=CC=1C[NH:6][C:7]1[S:11][C:10]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][C:8]=1[N+:16]([O-:18])=[O:17]>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:6][C:7]1[S:11][C:10]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][C:8]=1[N+:16]([O-:18])=[O:17]참가 물질
4
실험 절차
A solution of methyl 5-(2,4-dimethoxybenzylamino)-4-nitrothiophene-2-carboxylate 86 (40.3 mmol, 14.2 g) in CH2Cl2 (100 mL) and TFA (10 mL) was stirred overnight at rt. Reaction mixture was poured on ice and the precipitate was collected to give methyl 5-amino-4-nitrothiophene-2-carboxylate 87 (8.15 g, 100%). NMR (400 MHz, DMSO-d6) 3.77 (s, 3H), 7.75 (s, 1H), 9.06 (br s, 2H).
후처리
- customReaction mixture
- additionwas poured on ice
- customthe precipitate was collected
출처 및 근거
- ORD 기록
- ord-3e4ee040543d4e9fb457956a0816bcf5
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08669256B2
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