Tert-butyl thieno[2,3-b]pyrazin-6-ylcarbamate → Thieno[2,3-b]pyrazin-6-amine
반응식
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[S:7][C:8]([NH:10]C(=O)OC(C)(C)C)=[CH:9][C:2]=12>C(O)(C(F)(F)F)=O.C(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[S:7][C:8]([NH2:10])=[CH:9][C:2]=12참가 물질
4
실험 절차
A red solution of tert-butyl thieno[2,3-b]pyrazin-6-ylcarbamate (5.09 mmol, 1.28 g) in 66% TFA in CH2Cl2 25 mL was stirred overnight at room temperature The reaction mixture was concentrated in vacuo, dissolved in ethyl acetate, washed with NaHCO3 solution, brine, dried and evaporated to give thieno[2,3-b]pyrazin-6-amine 106 (620 mg, 81%). NMR (400 MHz, DMSO-d6) 5.98 (s, 1H), 7.17 (br s, 2H), 7.93 (d, J=2.7 Hz, 1H), 8.20 (d, J=2.7 Hz, 1H).
후처리
- concentrationwas concentrated in vacuo
- dissolutiondissolved in ethyl acetate
- washwashed with NaHCO3 solution, brine
- customdried
- customevaporated
출처 및 근거
- ORD 기록
- ord-a209f3cff04a47af9913001a005bfa9e
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08669256B2
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