8-Aminoquinoline → HCID 21973698, 화합물

HRID 11854

반응식

HRID 11854 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]1[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=1>CN(C=O)C>[N:10]1[C:11]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[NH:1][CH2:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=2)[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 113598-AminoquinolineHCID 11430Potassium CarbonateHCID 256687Methyl 4-(bromomethyl)benzoate

생성물 1

HCID 21973698HCID 21973698, 화합물수율 172.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

8-Aminoquinoline (1.26 g) was dissolved in DMF (20 ml), and potassium carbonate (1.2 g) and methyl 4-bromomethylbenzoate (1.0 g) were added. After stirring for 20 hours, the reaction solution was concentrated. The resulting residue was diluted with chloroform and water was added. The mixture was extracted with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain the title compound (2.20 g) as a yellow syrup.

후처리

  1. concentrationthe reaction solution was concentrated
  2. additionThe resulting residue was diluted with chloroform and water
  3. additionwas added
  4. extractionThe mixture was extracted with chloroform
  5. washThe organic layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2e776eb67f904408b46f21893414ce16
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098215B2

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