Thionyl Chloride → 4-Bromonaphthalene-1-carbonyl chloride

HRID 1185740노트

반응식

[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([OH:14])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([Cl:17])=[O:14])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 2825914-Bromo-1-naphthoic acid

생성물 1

HCID 147000244-Bromonaphthalene-1-carbonyl chloride

반응 조건

온도: 40 °C

실험 절차

4-Bromonaphthalene-1-carboxylic acid (9.80 g) was suspended in thionyl chloride (80 mL) and stirred at 40° C. for 16 hours and evaporated under vacuum. Solid was dissolved in DCM (20 mL) and evaporated under vacuum, giving 4-bromonaphthalene-1-carbonyl chloride (13.8 g, crude) as a white solid.

후처리

customevaporated under vacuum
dissolutionSolid was dissolved in DCM (20 mL)
customevaporated under vacuum

출처 및 근거

ORD 기록: ord-36e6cb4d4a1243de99c1ec72a9b57353
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08669234B2

반응 노트

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