2-Bromo-4'-methylacetophenone → 6-(Methoxycarbonyl)-2-(4-methylphenyl)imidazo[1,2-A]pyridine

HRID 1185991노트

반응식

HRID 1185991 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][N:14]=1>C(O)C>[C:8]1([CH3:11])[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 692722-Bromo-4'-methylacetophenoneHCID 737487Methyl 6-aminonicotinate

생성물 1

HCID 160882316-(Methoxycarbonyl)-2-(4-methylphenyl)imidazo[1,2-A]pyridine수율 85.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Bromo-4′-methylacetophenone 2 (14.5 g, 65.1 mmol) was added to a hot solution of methyl 2-aminopyridine-5-carboxylate 1 (9.0 g, 61.1 mmol) in ethanol (280 ml). The solution was then heated at reflux for 6 h, cooled to room temperature and the white solid filtered and washed with ethanol to give methyl 2-(4-tolyl)-imidazo[1,2-a]pyridine-6-carboxylate 3 (13.9 g, 80%).

후처리

  1. temperatureThe solution was then heated
  2. temperatureat reflux for 6 h
  3. filtrationthe white solid filtered
  4. washwashed with ethanol

출처 및 근거

ORD 기록
ord-07e84fe958d141a1bd7ef71b27958dfa
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673652B2

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