HCID 67358291, 화합물 → HCID 67357839, 화합물

HRID 1185993노트

반응식

HRID 1185993 반응식
O[CH:2]([C:6]1([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)[N:10]2[CH:11]=[C:12]([C:15]([O:17][CH3:18])=[O:16])[CH:13]=[CH:14][C:9]2=[N:8][CH2:7]1)[C:3]([OH:5])=[O:4]>C(O)=O.[Pd]>[CH3:18][O:17][C:15]([C:12]1[CH:13]=[CH:14][C:9]2[N:10]([C:6]([CH2:2][C:3]([OH:5])=[O:4])([C:19]3[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=3)[CH2:7][N:8]=2)[CH:11]=1)=[O:16]

참가 물질

4

반응물 1

HCID 67358291HCID 67358291, 화합물

생성물 1

HCID 67357839HCID 67357839, 화합물수율 97%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 284Formic Acid용매

실험 절차

To a solution of 4 (8.5 g, 25 mmol) in formic acid (100 ml) under nitrogen was added 10% palladium/carbon catalyst (600 mg) and the mixture heated at reflux overnight. The mixture was cooled to room temperature, filtered and evaporated to dryness. Water (100 ml) was added and the mixture stirred for 2 h. The white precipitate was filtered, washed with water (2×50 ml) and dried to give the light brown/yellow solid 2-[6-methoxycarbonyl-3-(4-tolyl)imidazo[1,2-a]pyridine-3-yl]acetic acid 5 (7.9 g, 97%).

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux overnight
  3. filtrationfiltered
  4. customevaporated to dryness
  5. additionWater (100 ml) was added
  6. filtrationThe white precipitate was filtered
  7. washwashed with water (2×50 ml)
  8. customdried

출처 및 근거

ORD 기록
ord-45ea17bfe196414d834bc17062081bc5
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673652B2

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